Mayersohn M
J Gerontol. 1982 May;37(3):300-5. doi: 10.1093/geronj/37.3.300.
A pharmacokinetic evaluation has been made of the literature that has examined xylose absorption as a function of age. Urinary xylose recovery during a 5-hour collection declines with age after oral and intravenous dosing. Calculated values for xylose renal clearance and elimination rate constant display a similar dependence upon age. The ratio of urinary recoveries after oral compared with intravenous dosing remains constant up to age 65 years but decreases after 70 years. Age appears to explain most of the variation associated with the above parameters. This analysis supports the suggestion made previously by several investigators that the xylose test as currently used to assess absorption in the elderly has not been properly interpreted.
已对研究木糖吸收随年龄变化情况的文献进行了药代动力学评估。口服和静脉给药后，5小时收集期间的尿木糖回收率随年龄增长而下降。木糖肾清除率和消除速率常数的计算值显示出对年龄的类似依赖性。口服与静脉给药后尿回收率的比值在65岁之前保持恒定，但在70岁之后下降。年龄似乎可以解释与上述参数相关的大部分变化。该分析支持了几位研究人员之前提出的建议，即目前用于评估老年人吸收情况的木糖试验尚未得到正确解读。
