老年人的药代动力学。
Pharmacokinetics in the elderly.
作者信息
Mayersohn M
机构信息
College of Pharmacy, University of Arizona, Tucson 85721, USA.
出版信息
Environ Health Perspect. 1994 Dec;102 Suppl 11(Suppl 11):119-24. doi: 10.1289/ehp.94102s11119.
Animals undergo substantial changes in many physiologic and biochemical functions as a natural consequence of aging. In the absence of disease or other pathologic conditions, these changes occur in a gradual manner with time (generally expressed as a fractional or percentage change in that function per year or decade). Furthermore, for any given function and at any given chronologic age, there is large variation in that function among individuals. Given the increase in life expectancy, the substantial increase in the number of elderly (and aged elderly) in the population, and the escalating costs of health care, there is great interest in learning more about the risks associated with aging as a result of toxic exposure. Are the elderly at greater risk than younger adults to the toxic effects of drugs and environmental exposure? Is the elderly population an inherently more sensitive one?
作为衰老的自然结果，动物在许多生理和生化功能方面会发生显著变化。在没有疾病或其他病理状况的情况下，这些变化会随着时间逐渐发生（通常表示为该功能每年或每十年的分数或百分比变化）。此外，对于任何给定的功能以及任何给定的实际年龄，个体之间在该功能上存在很大差异。鉴于预期寿命的增加、人口中老年（和高龄老年）人数的大幅增加以及医疗保健成本的不断攀升，人们对了解更多因接触毒物而导致的与衰老相关的风险非常感兴趣。老年人比年轻人更容易受到药物和环境暴露的毒性影响吗？老年人群体本质上更敏感吗？
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