Mann D M, Yates P O, Hawkes J
J Neurol Neurosurg Psychiatry. 1982 Feb;45(2):113-9. doi: 10.1136/jnnp.45.2.113.
The number of melanin containing nerve cells of the locus coeruleus and vagus nucleus is reduced in Alzheimer's disease by 60% with decrease of 22% in the protein synthetic capability of remaining cells. These changes are matched by reductions in brain noradrenaline in eight regions, averaging 36%. In multi-infarct dementia, however, all three of these features are unchanged. These findings indicate that degeneration of central noradrenergic nerve cells is a specific aspect of the pathogenic process underlying Alzheimer's disease.
在阿尔茨海默病中，蓝斑和迷走神经核中含黑色素的神经细胞数量减少了60%，剩余细胞的蛋白质合成能力下降了22%。这些变化与八个脑区中去甲肾上腺素的减少相匹配，平均减少36%。然而，在多发梗死性痴呆中，这三个特征均未改变。这些发现表明，中枢去甲肾上腺素能神经细胞的退化是阿尔茨海默病发病过程的一个特定方面。
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