Harris R L, Frenkel R A, Cottam G L, Baxter C R
J Trauma. 1982 Mar;22(3):194-8. doi: 10.1097/00005373-198203000-00004.
Lipid mobilization following thermal injury was studied in 25 patients with burns of between 35 and 95% TBSA for 30 to 50 days postinjury. The concentration of free fatty acids and glycerol in the plasma was elevated. The concentration of plasma triglycerides was elevated, while the concentration of ketone bodies remained normal. Thus it is suggested that the free fatty acids are primarily being re-esterified to triglycerides rather than being utilized for ketone body production. During the first 10 days postinjury, the plasma carnitine level was slightly decreased, while the concentration of carnitine in liver and muscle was elevated. The level of carnitine in burn wound fluid was similar to that in plasma. Therefore, the early decrease in plasma carnitine appeared to result from wound losses, as well as the sustained increased uptake by liver and muscle throughout the burn course.
对25例烧伤面积为35%至95%体表面积的患者在伤后30至50天内进行了热损伤后脂质动员的研究。血浆中游离脂肪酸和甘油的浓度升高。血浆甘油三酯浓度升高，而酮体浓度保持正常。因此，提示游离脂肪酸主要被重新酯化为甘油三酯，而不是用于酮体生成。在伤后的前10天，血浆肉碱水平略有下降，而肝脏和肌肉中的肉碱浓度升高。烧伤创面渗出液中的肉碱水平与血浆中的相似。因此，血浆肉碱早期下降似乎是由于创面丢失以及在整个烧伤过程中肝脏和肌肉持续增加摄取所致。
