McLaren D J, Terry R J
Parasite Immunol. 1982 Mar;4(2):129-48. doi: 10.1111/j.1365-3024.1982.tb00426.x.
Schistosomes grown in mice were tested at different stages of development for susceptibility to an in vitro cytotoxic effector mechanism involving eosinophils and an antibody directed against mouse determinants. Despite the fact that 5-day lung worms and 6-week adult worms both bound the antibody to their surfaces, eosinophils attached preferentially to the adults and killed them. Complement had an enhancing effect in this system. Those eosinophils which did adhere to the lung worms degranulated onto the tegument but were unable to mediate damage or killing, even when complement was activated at the parasite surface. The resistance shown by the lung worms was shared by 2-week worms and small 3-week worms. Larger 3-week worms and older stages were, however, susceptible to cell-mediated cytotoxicity in this system. We suggest that the host antigen disguise constitutes the major protective mechanism utilized by older schistosomes to evade immunity, but that the younger stages have an additional and equally effective mechanism of resistance.
对在小鼠体内生长的血吸虫在不同发育阶段进行测试，以检测其对一种涉及嗜酸性粒细胞和针对小鼠决定簇的抗体的体外细胞毒性效应机制的敏感性。尽管5日龄的肺期虫和6周龄的成虫都能将抗体结合到其表面，但嗜酸性粒细胞优先附着于成虫并将其杀死。补体在该系统中具有增强作用。那些确实附着在肺期虫上的嗜酸性粒细胞会在虫体表膜上脱颗粒，但即使在寄生虫表面激活补体，也无法介导损伤或杀伤。2周龄的虫和3周龄的小虫子与肺期虫表现出相同的抗性。然而，3周龄较大的虫子和更老阶段的虫子在该系统中易受细胞介导的细胞毒性作用影响。我们认为，宿主抗原伪装是较成熟血吸虫用于逃避免疫的主要保护机制，但较年轻阶段具有另一种同样有效的抗性机制。
