对照受试者和囊性纤维化患者成纤维细胞中的钙与年龄
Calcium and age in fibroblasts from control subjects and patients with cystic fibrosis.
作者信息
Shapiro B L, Lam L F
出版信息
Science. 1982 Apr 23;216(4544):417-9. doi: 10.1126/science.7071590.
PMID:7071590
Abstract
Intracellular calcium increases significantly as human fibroblasts age in culture. The calcium increase occurs 5 to 6 weeks (passages) earlier and is significantly greater in fibroblasts from subjects with cystic fibrosis in comparison with cells from control subjects. Intracellular calcium, which is thought to be a pathogenetic factor in cystic fibrosis, may also be a meaningful marker in cell aging.
摘要
随着人类成纤维细胞在培养中老化，细胞内钙显著增加。钙增加发生的时间比正常情况早5至6周（传代次数），并且与对照受试者的细胞相比，囊性纤维化受试者的成纤维细胞内钙增加幅度明显更大。细胞内钙被认为是囊性纤维化的致病因素，它也可能是细胞衰老的一个有意义的标志物。
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