Hoffman M, Avellone J C, Plecha F R, Rhodes R S, Donovan D L, Beven E G, DePalma R G, Frisch J A
Surgery. 1982 May;91(5):597-602.
From 1975 through 1979, 29 members of The Cleveland Vascular Society operated on 1049 patients with abdominal aortic aneurysms; of these, 152 ruptured aneurysms. The postoperative mortality rate was 38% (58 of 152). In 27% (41 of 152) of the patients, a diagnosis was made prior to rupture, and the average interval from diagnosis rupture was 16 months. A history of diabetes, hypertension, or a single myocardial infarction (MI) prior to rupture was not associated with an increased mortality rate. Patients with a history of more than one MI prior to rupture had a 75% (six of eight) mortality rate. The average time from onset of symptoms to examination was 2 days 10 hours. When the initial diagnosis was correct, or an intra-abdominal disease was at least suspected, the mortality rate was 35% (47 of 135). When the initial diagnosis was incorrect and a cardiopulmonary or cerebral cause was suspected, the mortality rate was 75% (13 of 17). When the diagnosis was incorrect, the interval from diagnosis to surgery was 2 1/2 days. With only intramural bleeding or a small hematoma in the area of rupture, the mortality rate was 17% (4 of 24); when the hematoma was more extensive, the mortality rate was 43% (55 of 128). This study encompassed a large number of operations performed in a metropolitan area during a relatively short period of time, during which there had been few changes in operative technique or supportive measures. It demonstrated that the most critical factors influencing survival were correct initial diagnosis, the extent of the hematoma, and the history of more than one preoperative MI.
1975年至1979年期间,克利夫兰血管外科学会的29名成员为1049例腹主动脉瘤患者实施了手术;其中有152例动脉瘤破裂。术后死亡率为38%(152例中的58例)。27%(152例中的41例)的患者在动脉瘤破裂前得到了诊断,从诊断到破裂的平均间隔时间为16个月。破裂前有糖尿病、高血压病史或单次心肌梗死(MI)与死亡率增加无关。破裂前有不止一次心肌梗死病史的患者死亡率为75%(8例中的6例)。从症状出现到接受检查的平均时间为2天10小时。当初始诊断正确,或至少怀疑有腹腔内疾病时,死亡率为35%(135例中的47例)。当初始诊断错误且怀疑是心肺或脑部原因时,死亡率为75%(17例中的13例)。诊断错误时,从诊断到手术的间隔时间为2.5天。仅存在壁内出血或破裂部位有小血肿时,死亡率为17%(24例中的4例);血肿范围较大时,死亡率为43%(128例中的55例)。本研究涵盖了在一个大都市地区相对较短时间内进行的大量手术,在此期间手术技术或支持措施几乎没有变化。研究表明,影响生存的最关键因素是初始诊断正确、血肿范围以及术前有不止一次心肌梗死病史。