Komar V I
Vopr Pitan. 1982 Jan-Feb(1):26-9.
The microbiological method was used in 168 virus hepatitis patients aged 16-55 years to study the content of unbound vitamin B12 in the blood serum over the time of the disease before administration of cyanocobalamin and in the course of its application in a dose of 100 and 200 micrograms intramuscularly every other day for 3-4 weeks. In the acute stage of the disease, the patients showed an appreciable hypercyanocobalaminemia that correlated well with the disease severity and with the magnitudes of liver function tests. Cyanocobalamin administered to the patients intramuscularly in a dose of 100 micrograms every other day exerted a more remarkable normalizing effect on the level of unbound vitamin B12, bilirubin, the thymol test, aldolase and alanine aminotransferase of the blood as compared to that produced by the drug injected in a dose of 200 micrograms.
采用微生物学方法对168例年龄在16至55岁的病毒性肝炎患者进行研究，观察在给予氰钴胺之前疾病期间以及每隔一天肌肉注射100微克和200微克剂量的氰钴胺并持续3至4周的过程中血清中游离维生素B12的含量。在疾病急性期，患者出现明显的高氰钴胺血症，这与疾病严重程度以及肝功能检查指标密切相关。与每隔一天肌肉注射200微克剂量的药物相比，每隔一天肌肉注射100微克剂量的氰钴胺对血液中游离维生素B12、胆红素、麝香草酚浊度试验、醛缩酶和谷丙转氨酶水平具有更显著的正常化作用。
