Mortensen P T
Acta Anaesthesiol Scand. 1982 Feb;26(1):48-52. doi: 10.1111/j.1399-6576.1982.tb01724.x.
In a double-blind investigation, comprising 300 gynaecological patients, the prophylactic use of droperidol i.v. at the start of the anaesthesia produced significant reduction in the frequency of nausea and vomiting postoperatively in the first 24 h from 34.4% to 10.3% (P=0.0001). There was no significant difference between the effect of droperidol 2.5 mg and 5 mg (P=0.45). Increased postoperative sedation was the only side-effect of any importance observed; however, this did not result in any increased period of observation in the recovery room, and the majority of patients considered it advantageous. Droperidol is recommended as a prophylactic anti-emetic for selected groups of patients, given as 2.5 mg i.v. at the start of the anaesthesia.
在一项包括300名妇科患者的双盲研究中，麻醉开始时静脉注射氟哌利多进行预防性用药，使术后24小时内恶心和呕吐的发生率从34.4%显著降至10.3%（P=0.0001）。2.5毫克和5毫克氟哌利多的效果之间无显著差异（P=0.45）。观察到的唯一重要副作用是术后镇静作用增强；然而，这并未导致在恢复室的观察时间增加，且大多数患者认为这是有利的。推荐将氟哌利多作为特定患者群体的预防性止吐药，在麻醉开始时静脉注射2.5毫克。
