术后恶心呕吐：单独使用或联合使用的止吐药物比较
Postoperative nausea and vomiting: a comparison of anti-emetic drugs used alone or in combination.
作者信息
Michaloudis D, O'Keeffe N, O'Sullivan K, Healy T E
机构信息
Department of Anaesthesia, Withington Hospital, Manchester.
出版信息
J R Soc Med. 1993 Mar;86(3):137-8. doi: 10.1177/014107689308600306.
Abstract
Drugs with anti-emetic properties can exert their actions at more than one receptor site, histamine H1, muscarinic cholinergic or dopaminergic D2 receptors. This study was designed to test the hypothesis that a combination of drugs acting at different receptor sites in lower than standard doses would be at least as effective as a standard therapeutic dose of a single anti-emetic agent. A combination of droperidol, hyoscine and metoclopramide in subtherapeutic doses has been shown to be at least as effective as droperidol (1.25 mg) alone. In both groups there was a low incidence of emetic sequelae in the first 3 hours postoperatively.
摘要
具有止吐特性的药物可在不止一个受体部位发挥作用，如组胺H1、毒蕈碱胆碱能或多巴胺能D2受体。本研究旨在验证以下假设：以低于标准剂量作用于不同受体部位的药物组合，其效果至少与单一止吐剂的标准治疗剂量相同。已证明，小剂量氟哌利多、东莨菪碱和甲氧氯普胺的组合至少与单独使用氟哌利多（1.25毫克）一样有效。两组术后前3小时呕吐后遗症的发生率均较低。
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