Tobe K
Acta Pathol Jpn. 1982 Jan;32(1):57-70. doi: 10.1111/j.1440-1827.1982.tb02027.x.
Liver biopsy specimens from a primary biliary cirrhosis (PBC) patient and two control patients with other biliary disorders were examined under the electron microscope, with special reference to intrahepatic bile ducts. The PBC patient had a bile duct with an 80 micrometers diameter that showed specific alterations in epithelial cells. These cells were termed oncocytes, and their main features were: the presence of a large number of swollen mitochondria with abnormal cristae, no mitochondrial bodies, small number of exocrine granules and an undulated nucleus with a large cytoplasm. The number of mitochondria per ultrathin-sectioned epithelial cell was greater by about 2 times in the oncocytic epithelial cells compared to the control cells. Fine fibrils and long-spacing collagens were present around the PBC bile duct. Periductal capillaries of the bile duct had multilayered basement membranes. These periductal changes may have induced the oncocytic changes in the epithelial cells. The basement membrane of the bile duct was meandrous and often disrupted, but not multilayered. Many lymphocytes and macrophages infiltrated among the epithelial cells.
对一名原发性胆汁性肝硬化（PBC）患者以及两名患有其他胆汁紊乱疾病的对照患者的肝活检标本进行了电子显微镜检查，特别关注肝内胆管。该PBC患者有一条直径为80微米的胆管，其上皮细胞呈现出特定改变。这些细胞被称为嗜酸性细胞，其主要特征为：存在大量肿胀且嵴异常的线粒体，无线粒体体，少量外分泌颗粒，以及一个带有大细胞质的起伏核。与对照细胞相比，嗜酸性上皮细胞中每个超薄切片上皮细胞的线粒体数量大约多两倍。PBC胆管周围存在细纤维和长间距胶原。胆管的导管周围毛细血管有多层基底膜。这些导管周围变化可能诱导了上皮细胞的嗜酸性改变。胆管的基底膜呈蜿蜒状且常被破坏，但并非多层。许多淋巴细胞和巨噬细胞浸润在上皮细胞之间。
