Kaye W H, Pickar D, Naber D, Ebert M H
Am J Psychiatry. 1982 May;139(5):643-5. doi: 10.1176/ajp.139.5.643.
The authors found higher levels of CSF opioid activity, determined by radioreceptor assay, in patients with anorexia nervosa who were severely underweight than in 1) the same patients after weight restoration and 2) normal controls. Another group of patients who had chronic anorexia nervosa but were not severely underweight had normal levels of CSF opioid activity. Endogenous opioid systems have been shown to be related to eating behavior and metabolic regulation in animals. The association between decreased weight and increased CSF opioid activity observed by the authors may be a compensatory response to weight loss or may be etiologically related to anorexia nervosa.
作者发现，通过放射受体测定法确定，与1）体重恢复后的同一批患者以及2）正常对照组相比，严重体重过轻的神经性厌食症患者脑脊液中的阿片样物质活性水平更高。另一组患有慢性神经性厌食症但体重并非严重过轻的患者脑脊液阿片样物质活性水平正常。内源性阿片样物质系统已被证明与动物的进食行为和代谢调节有关。作者观察到的体重减轻与脑脊液阿片样物质活性增加之间的关联可能是对体重减轻的一种代偿反应，或者可能在病因上与神经性厌食症有关。
