Chen B Q, Beaty B J
Am J Trop Med Hyg. 1982 Mar;31(2):403-7. doi: 10.4269/ajtmh.1982.31.403.
The Japanese encephalitis vaccine virus (JE 2-8) and its parent virus (JE SA 14) strains were compared for their ability to infect, to replicate in, and to be transmitted by Culex tritaeniorhynchus mosquitoes. Both viruses replicated in the mosquitoes after intrathoracic infection. The JE 2-8 vaccine was transmitted to 1/36 (3%) of suckling mice bitten by intrathoracically infected mosquitoes; however, the parent JE SA 14 strain was transmitted to 46/46 (100%) of the mice bitten. In oral infection trials, only 4/36 (11%) of the Cx. tritaeniorhynchus mosquitoes ingesting the vaccine JE 2-8 strain became infected, whereas 19/19 (100%) of those ingesting the parent JE SA 14 strain became infected. The vaccine JE 2-8 strain did not revert to virulence during passage in mosquitoes.
对日本脑炎疫苗病毒（JE 2-8）及其亲本病毒（JE SA 14）毒株在感染三带喙库蚊、在其体内复制以及通过其传播的能力方面进行了比较。两种病毒经胸腔内感染后均能在蚊子体内复制。被经胸腔内感染的蚊子叮咬的乳鼠中，JE 2-8疫苗病毒传播给了1/36（3%）的乳鼠；然而，亲本JE SA 14毒株传播给了被叮咬的46/46（100%）的乳鼠。在经口感染试验中，摄入疫苗JE 2-8毒株的三带喙库蚊中只有4/36（11%）被感染，而摄入亲本JE SA 14毒株的蚊子中19/19（100%）被感染。疫苗JE 2-8毒株在蚊子传代过程中未恢复毒力。
