Wiedemann K, Bauer P K, Schütze U, Hanf K
Anaesthesist. 1982 Jan;31(1):39-43.
Eight beagle dogs were anaesthetized with 1-methadone and nitrous oxide under controlled ventilation. By means of previously implanted strain gauges circular and longitudinal contractions of ileum colon were recorded for 60 min before and 60 min following injection of pancuronium bromide (pcb) 0.08 mg/kg KG I.V. The areas under the contraction curves before and following injection were summed to yield two respective motility indices (dimension N. sec). These indices for circular and longitudinal musculature in the ileum were 14,876 +/- 7,977 and 6,825 +/- 3,172 before and 12,162 +/- 7,772 and 12,565 +/- 5,538 after pcb. For circular and longitudinal colonic musculature they were 10,244 +/- 2,643 and 15,542 +/- 2,460 before and 10,175 +/- 7,030 and 19,825 +/- 10,617 after PCB. The differences were not statistically significant. It is concluded, that pancuronium bromide had no demonstrable effect on spontaneous jejunal and colonic motility.
八只比格犬在控制通气条件下用美沙酮和一氧化二氮麻醉。借助先前植入的应变片，在静脉注射0.08mg/kg体重的泮库溴铵（pcb）之前60分钟和之后60分钟记录回肠结肠的环形和纵向收缩情况。将注射前后收缩曲线下的面积相加，得出两个相应的运动指数（单位：N.秒）。回肠环形和纵向肌肉组织的这些指数在注射pcb之前分别为14,876±7,977和6,825±3,172，之后分别为12,162±7,772和12,565±5,538。对于结肠环形和纵向肌肉组织，在注射pcb之前分别为10,244±2,643和15,542±2,460，之后分别为10,175±7,030和19,825±10,617。这些差异无统计学意义。得出的结论是，泮库溴铵对空肠和结肠的自发运动没有明显影响。
