Emadian S M, Caravati E M, Herr R D
Department of Neurosurgery, University of Utah Health Sciences Center, Salt Lake City 84132, USA.
Am J Emerg Med. 1996 Oct;14(6):574-6. doi: 10.1016/S0735-6757(96)90103-5.
Drug- and toxin-induced rhabdomyolysis is a nonspecific clinical syndrome resulting from the release of skeletal muscle cell contents into the plasma and urine. Antihistamine drugs are the active ingredients in a number of over-the-counter preparations and are frequently ingested in suicide attempts. We report rhabdomyolysis as a rare adverse effect of diphenhydramine toxicity in a 29-year-old man who ingested an unknown quantity of an over-the-counter sleep preparation in a suicide attempt. The patient had documented toxic concentration of diphenhydramine in his cerebrospinal fluid and no history of seizures, coma, or hypothermia. A high index of suspicion and an evaluation for rhabdomyolysis is warranted in antihistamine toxicity.
药物和毒素诱导的横纹肌溶解是一种非特异性临床综合征，由骨骼肌细胞内容物释放到血浆和尿液中引起。抗组胺药是多种非处方药制剂中的活性成分，常被用于自杀企图。我们报告了一例29岁男性因服用未知剂量的非处方睡眠制剂自杀未遂后，横纹肌溶解作为苯海拉明中毒罕见不良反应的病例。该患者脑脊液中苯海拉明浓度已证实达到中毒水平，且无癫痫、昏迷或体温过低病史。对于抗组胺药中毒，应高度怀疑并评估是否存在横纹肌溶解。
