Arvidson G A, Asp N G
Ann Nutr Metab. 1982;26(1):12-7. doi: 10.1159/000176538.
In the rat, exclusion of choline from a carbohydrate-rich, 10% casein diet, resulted in a drastic reduction of betaine in the liver. The amount of unesterified choline was not lowered to the same extent. Both unesterified choline and total lipids in the liver were increased by rats fed a choline-deficient diet supplemented with 0.5% L-methionine compared to rats given an unsupplemented choline-deficient diet. The amount of betaine was low in both groups compared to choline-supplemented rats. Dietary choline deficiency lowered the biological value of casein only slightly. Statistically significant effects were seen only in some of the experiments when potato starch was used as the carbohydrate source but not when maize starch was used. The choline-deficient potato starch diet gave rise to a more severe liver fattening that the corresponding maize starch diet.
在大鼠中，从富含碳水化合物的10%酪蛋白饮食中排除胆碱，导致肝脏中甜菜碱急剧减少。未酯化胆碱的量没有降低到相同程度。与喂食未补充胆碱的缺乏胆碱饮食的大鼠相比，喂食补充了0.5% L-蛋氨酸的缺乏胆碱饮食的大鼠，其肝脏中的未酯化胆碱和总脂质均增加。与补充胆碱的大鼠相比，两组中的甜菜碱含量都很低。饮食中胆碱缺乏仅略微降低了酪蛋白的生物学价值。仅在一些以马铃薯淀粉作为碳水化合物来源的实验中观察到统计学上的显著影响，而以玉米淀粉作为碳水化合物来源时则未观察到。缺乏胆碱的马铃薯淀粉饮食比相应的玉米淀粉饮食导致更严重的肝脏脂肪堆积。
