Uthus E O, Nielsen F H
USDA, ARS, Grand Forks Human Nutrition Research Center, ND 58202.
Biol Trace Elem Res. 1988 Jul;16(2):155-64. doi: 10.1007/BF02797100.
In two fully crossed, two-factor experiments, F1 generation male rats were fed a basal diet supplemented with lead (lead acetate) at 0 or 2 micrograms/g and iron (ferric sulfate) at 50 or 250 micrograms/g (Experiment 1). Supplements in Experiment 2 were lead at 0 or 1 micrograms/g and iron at 50, 250, or 1000 micrograms/g. After 28 or 50 d in Experiment 1, and 35 d in Experiment 2, a relationship between lead and iron was found. Body weight was lower in low-lead than lead-supplemented 28-d-old rats regardless of dietary iron, whereas hematocrit and hemoglobin were lower in low-lead than lead-supplemented rats fed 50 micrograms iron/g diet. A similar finding was obtained with hematocrit and hemoglobin in 35-d-old rats. Dietary lead did not affect rats fed 250 or 1000 micrograms iron/g diet. Also, feeding low dietary lead did not affect 50-d-old rats regardless of dietary iron. Liver and bone concentrations of lead were markedly affected by dietary lead and iron. The concentration of lead in liver and bone was lower in low-lead than lead-supplemented rats. Compared to rats fed 50 micrograms iron/g diet, rats fed 250 micrograms iron/g diet exhibited a decreased lead concentration in liver and bone. This decrease was accentuated by lead supplementation. The findings suggest that lead acted pharmacologically to affect iron metabolism in rats.
在两项完全交叉的双因素实验中，给F1代雄性大鼠喂食基础日粮，分别补充0或2微克/克的铅（醋酸铅）以及50或250微克/克的铁（硫酸铁）（实验1）。实验2中的补充剂为0或1微克/克的铅以及50、250或1000微克/克的铁。在实验1中饲养28天或50天后，以及在实验2中饲养35天后，发现了铅与铁之间的关系。无论日粮中铁的含量如何，低铅组28日龄大鼠的体重均低于补充铅的大鼠，而低铅组大鼠的血细胞比容和血红蛋白低于日粮中添加50微克铁/克的补充铅的大鼠。在35日龄大鼠的血细胞比容和血红蛋白方面也得到了类似的结果。日粮铅对喂食250或1000微克铁/克日粮的大鼠没有影响。此外，无论日粮中铁的含量如何，低日粮铅喂养对50日龄大鼠也没有影响。肝脏和骨骼中的铅浓度受到日粮铅和铁的显著影响。低铅组大鼠肝脏和骨骼中的铅浓度低于补充铅的大鼠。与喂食50微克铁/克日粮的大鼠相比，喂食250微克铁/克日粮的大鼠肝脏和骨骼中的铅浓度降低。铅补充会加剧这种降低。这些发现表明，铅在药理上对大鼠的铁代谢有影响。
