Voors A W, Shuman M S, Johnson W D
Arch Environ Health. 1982 Mar-Apr;37(2):98-102. doi: 10.1080/00039896.1982.10667544.
The association of heart-related mortality with tissue cadmium and lead in a study of autopsies performed on persons who resided in a soft-water, leached-soil area of North Carolina was examined. Liver cadmium concentrations and aortic lead level were indices of these elements. Both cadmium and lead levels had statistically significant correlations with cause of death (heart-related disease vs. non-heart-related disease, excluding cancer). Although cause of death was significantly associated with age, the association with cadmium and lead persisted after statistical adjustment for the effect of age. The combined effects of cadmium and lead provided sufficient information in an additive model to predict cause of death correctly for 80% of the cases, with age contributing insignificantly. These findings indicate the intimate relation of these two trace metals with increased risk of heart-related mortality, even in light of known conventional causes of such deaths.
在一项对居住在北卡罗来纳州软水、土壤淋溶地区的人群进行尸检的研究中，研究了与心脏相关的死亡率与组织镉和铅之间的关联。肝脏镉浓度和主动脉铅水平是这些元素的指标。镉和铅水平与死因（心脏相关疾病与非心脏相关疾病，不包括癌症）均具有统计学上的显著相关性。尽管死因与年龄显著相关，但在对年龄影响进行统计调整后，与镉和铅的关联仍然存在。在一个相加模型中，镉和铅的综合效应提供了足够的信息，能够正确预测80%病例的死因，而年龄的影响微不足道。这些发现表明，即使考虑到此类死亡的已知传统原因，这两种痕量金属与心脏相关死亡率增加之间存在密切关系。
