Zeitels J, Naunheim K, Kaplan E L, Straus F
Arch Surg. 1982 May;117(5):732-7. doi: 10.1001/archsurg.1982.01380290176031.
We analyzed 101 cases of carcinoid tumor in patients treated at the University of Chicago hospitals between 1942 and 1979. Tumors occurred most commonly in the rectum (29%) and ileum (28%). Only 12% were appendiceal. More than 60% were less than 1 cm, and 43% were confined to the submucosa. These factors led to favorable prognoses. Twenty-three percent of the tumors were greater than 2 cm in diameter; 70% of them had metastasized, compared with only 6% of lesions less than 1 cm. Metastases were present in 46% of ileal and 40% of colonic lesions. None of 13 bronchial and only one of 12 appendiceal lesions demonstrated this spread. Carcinoid syndrome was noted in three cases. A second neoplasm was present in 22%. The corrected five-year survival rate was 87% overall, 95% without metastases, 83% with positive regional lymph nodes, and only 40% with distant spread.
我们分析了1942年至1979年间在芝加哥大学医院接受治疗的101例类癌患者。肿瘤最常见于直肠（29%）和回肠（28%）。仅12%发生于阑尾。超过60%的肿瘤小于1厘米，43%局限于黏膜下层。这些因素导致预后良好。23%的肿瘤直径大于2厘米；其中70%已发生转移，而小于1厘米的病变仅有6%发生转移。46%的回肠病变和40%的结肠病变存在转移。13例支气管病变均无转移，12例阑尾病变中仅1例有转移。3例出现类癌综合征。22%的患者存在第二种肿瘤。总体校正五年生存率为87%，无转移者为95%，区域淋巴结阳性者为83%，远处转移者仅为40%。
