Biopsy of human olfactory mucosa. An instrument and a technique.

We have developed an instrument that obtains small biopsy specimens of human olfactory mucosa suitable for electron microscopy. Following local anesthesia of the patient, the instrument is introduced through the naris and advanced 60 to 70 mm between the septum and middle turbinate. The cutting edge is pressed against the olfactory area and then is withdrawn with the mucosal specimen. This procedure has been performed successfully on 12 people with no substantial adverse effects. We have provided the indications for the use of this technique and its possible applications.