Jafek Bruce W, Murrow B, Michaels R, Restrepo D, Linschoten M
Rocky Mountain Taste and Smell Center, Department of Otolaryngology-Head and Neck Surgery, UCHSC (B-205), 4200 East Ninth Avenue, Denver, CO 80262, USA.
Chem Senses. 2002 Sep;27(7):623-8. doi: 10.1093/chemse/27.7.623.
It has been shown that olfactory epithelium can be safely biopsied from the living, intact human being. Observations of the ultrastructure of this epithelium shows changes that can then be correlated with the etiology and degree of olfactory loss, allowing a greater understanding of both normal transduction and of the pathology of dysfunction. Examples of the common forms of olfactory dysfunction are presented and discussed. Additionally, the technique will allow additional immuno-histochemical and molecular study of the tissue, will increase the understanding of both normal and pathological function and should translate to new therapeutic regimens.
研究表明，可从活体完整人体安全获取嗅上皮组织进行活检。对该上皮组织超微结构的观察显示出一些变化，这些变化随后可与嗅觉丧失的病因及程度相关联，从而有助于更深入地了解正常转导过程以及功能障碍的病理学机制。文中列举并讨论了嗅觉功能障碍的常见形式。此外，该技术将使对该组织进行更多免疫组织化学和分子研究成为可能，有助于增进对正常和病理功能的理解，有望转化为新的治疗方案。
