胆结石形成人群的血清和肝脏脂质特征分析。
Characterization of serum and liver lipids of gallstone-forming humans.
作者信息
Chenouda M S, Gardner B
出版信息
Br J Exp Pathol. 1982 Apr;63(2):144-6.
Liver biopsy and serum specimens obtained from patients with cholesterol gallstones and from a control group were analysed for their different lipids and lipoprotein fractions. The ratio of free cholesterol to esterified cholesterol (CF/CE) was significantly (P less than 0.001) higher in the livers of gallstone-forming patients. There was no significant difference in the levels of total lipids, total cholesterol, phospholipids and glycerides. Beta-lipoprotein fraction (LDL) was higher in gallstone-forming patients. It is concluded that the decrease in esterified cholesterol of gallstone-formers may provide an important clue to an understanding of the physiology and chemistry of stone-formation in humans.
对从胆固醇结石患者和对照组获取的肝活检组织及血清样本进行分析，以检测其不同的脂质和脂蛋白组分。在形成胆结石的患者肝脏中，游离胆固醇与酯化胆固醇的比例（CF/CE）显著更高（P小于0.001）。总脂质、总胆固醇、磷脂和甘油酯水平无显著差异。形成胆结石的患者β-脂蛋白组分（低密度脂蛋白）更高。得出的结论是，胆结石形成者酯化胆固醇的减少可能为理解人类结石形成的生理和化学过程提供重要线索。
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