[Two stages of contact interaction of liposomes with bimolecular lipid membranes].

Interaction of liposomes with BLM is confirmed to consist of two stages. The first stage is a semi-fusion of liposomes with BLM. On this stage the bilayer in a contact area is formed of one liposome monolayer and another one of BLM. The second stage is inclusion of liposome bilayers into BLM; it occurs some tens of minutes after the first one. It occurs either by fusion or incorporation. The fusion to incorporation ratio increases with temperature. Liposomes are incorporated in BLM asymmetrically: the contact area of the liposome bilayer is always smaller than the free one.