Li A K, Koroly M J, Jeppsson B W, Schattenkerk M E, Young M, Malt R A
Br J Surg. 1982 Apr;69(4):212-4. doi: 10.1002/bjs.1800690414.
Increased salivary flow stimulated by intravenous isoproterenol (IPR) (6 mg/kg) doubled the incidence of gastric stress ulceration in normal male mice, but not after submandibular sialadenectomy. The submandibular salivary glands in these mice secrete large amounts of several growth factors, including epidermal growth factor (EGF) and nerve growth factor (NGF). Intragastric instillation of a quantity of high molecular weight NGF equimolar to that in IPR-stimulated saliva doubled the incidence of stress ulcers after submandibular sialadenectomy. This action of NGF in vivo is not mediated by its nerve growth promoting properties nor its plasminogen activating property.
静脉注射异丙肾上腺素（IPR）（6毫克/千克）刺激唾液分泌增加，使正常雄性小鼠胃应激性溃疡的发生率加倍，但在切除下颌下腺后则不会出现这种情况。这些小鼠的下颌下唾液腺分泌大量的几种生长因子，包括表皮生长因子（EGF）和神经生长因子（NGF）。胃内灌注与IPR刺激唾液中分子量相当的高分子量NGF，可使下颌下腺切除术后应激性溃疡的发生率加倍。NGF在体内的这种作用并非由其促进神经生长的特性或其纤溶酶原激活特性介导。
