Read N W, Read M G, Krejs G J, Hendler R S, Davis G, Fordtran J S
Dig Dis Sci. 1982 Mar;27(3):193-201. doi: 10.1007/BF01296914.
The purpose of this paper is to report five patients with chronic secretory diarrhea (maximum stool volume greater than 1 liter per day, duration 6 weeks to 8 years) in whom we could find no evidence of an endocrine tumor or of surreptitious laxative ingestion. All except one had severe hypokalemia. There was apparent improvement after treatment with prednisone in two patients and loperamide in one. The diarrhea resolved spontaneously in three patients and has undergone several temporary remissions in one patient. The last patient died after a severe unremitting illness. Extensive investigations failed to establish the etiology, but intestinal perfusion (carried out in four of the five patients) revealed secretion or abnormally low absorption of water and electrolytes in the jejunum and abnormally low absorption in the colon. The management of patients with chronic watery diarrhea is discussed.
本文旨在报告5例慢性分泌性腹泻患者（最大粪便量大于每天1升，病程6周至8年），在这些患者中，我们未发现内分泌肿瘤或隐匿性服用泻药的证据。除1例患者外，其他患者均有严重低钾血症。2例患者接受泼尼松治疗后明显好转，1例患者接受洛哌丁胺治疗后好转。3例患者腹泻自行缓解，1例患者经历了几次短暂缓解。最后1例患者在经历严重的持续疾病后死亡。广泛的检查未能确定病因，但肠道灌注（5例患者中的4例进行了此项检查）显示空肠存在水和电解质分泌或吸收异常低下，结肠存在吸收异常低下。本文还讨论了慢性水样腹泻患者的管理。
