Charley M R, Sontheimer R D
J Am Acad Dermatol. 1982 Apr;6(4 Pt 1):529-33. doi: 10.1016/s0190-9622(82)70045-3.
A patient with widespread subacute cutaneous lupus erythematosus (SCLE) developed halos of uninflamed, normal-appearing skin around lesions of molluscum contagiosum. A biopsy confirmed the lack of active lupus erythematosus (LE) in the halo area (neither basal layer liquefaction nor inflammatory infiltrate was present). Direct immunofluorescence of the halo area showed only weak staining with IgG and C3. In contrast, adjacent skin, clinically involved with cutaneous LE, showed both active LE by light microscopy and strong staining with IgG and C3. We feel the molluscum contagiosum lesions that developed in areas of active SCLE somehow suppressed the clinical, histologic, and immunologic expression of SCLE in he surrounding skin. This observation might offer some insight into the poorly understood pathophysiologic mechanisms involved in cutaneous LE.
一名患有广泛亚急性皮肤型红斑狼疮（SCLE）的患者，在传染性软疣皮损周围出现了一圈未发炎、外观正常的皮肤晕。活检证实晕区缺乏活动性红斑狼疮（LE）（既无基底层液化也无炎性浸润）。晕区的直接免疫荧光仅显示IgG和C3弱阳性染色。相比之下，临床上有皮肤型LE的相邻皮肤，经光学显微镜检查显示有活动性LE，且IgG和C3染色强。我们认为，在活动性SCLE区域出现的传染性软疣皮损，以某种方式抑制了周围皮肤中SCLE的临床、组织学和免疫学表现。这一观察结果可能有助于深入了解皮肤型LE中尚未完全理解的病理生理机制。
