Bangert J L, Freeman R G, Sontheimer R D, Gilliam J N
Arch Dermatol. 1984 Mar;120(3):332-7.
Subacute cutaneous lupus erythematosus (SCLE) is a recently described distinct subset of lupus erythematosus (LE) having characteristic clinical, serologic, and genetic findings. This study describes the histopathologic characteristics of SCLE and determines whether it could be differentiated from discoid lupus erythematosus (DLE) on histopathologic grounds alone. Biopsy specimens from 33 patients having either SCLE or DLE, as defined by strict clinical criteria, were examined without knowledge of the clinical diagnosis. Histologic discrimination between SCLE and DLE was accomplished in 82%. The specimens from DLE lesions had substantially more hyperkeratosis, basement membrane thickening, follicular plugging, and superficial and deep inflammatory cell infiltrate, while SCLE had more epidermal atrophy. The histopathologic differences between SCLE and DLE further support the concept that SCLE is distinct from DLE and should be considered a unique subset of LE.
亚急性皮肤型红斑狼疮（SCLE）是最近被描述的红斑狼疮（LE）的一个独特亚型，具有特征性的临床、血清学和遗传学表现。本研究描述了SCLE的组织病理学特征，并确定仅根据组织病理学依据能否将其与盘状红斑狼疮（DLE）区分开来。在不知道临床诊断的情况下，对33例根据严格临床标准定义为患有SCLE或DLE的患者的活检标本进行了检查。82%的病例实现了SCLE和DLE的组织学鉴别。DLE病变的标本有明显更多的角化过度、基底膜增厚、毛囊堵塞以及浅表和深部炎症细胞浸润，而SCLE有更多的表皮萎缩。SCLE和DLE之间的组织病理学差异进一步支持了SCLE不同于DLE且应被视为LE的一个独特亚型的观点。
