Kyong C U, Ponce B E, Fudenberg H H, Glassman A B, Mohrmann M E
J Allergy Clin Immunol. 1982 May;69(5):444-7. doi: 10.1016/0091-6749(82)90119-1.
The capacity of polymorphonuclear leukocytes (PMNs) to kill Staphylococcus aureus strains 502 A was studied in 25 patients receiving theophylline therapy and in normal healthy controls. A significant difference in PMN bactericidal capacity was found between controls and patients with serum theophylline levels higher than 8 micrograms/ml, as determined by high-pressure liquid chromatography. The bactericidal capacity of PMNs from both the patient and control populations was reduced in the presence of theophylline levels above 8 micrograms/ml. In addition, a transient but significant drug-independent reduction was found in the bactericidal capacity of transient but significant drug-independent reduction was found in the bactericidal capacity of PMNs from patients receiving theophylline.
在25例接受茶碱治疗的患者和正常健康对照中，研究了多形核白细胞（PMN）杀灭金黄色葡萄球菌502A菌株的能力。通过高压液相色谱法测定，对照组与血清茶碱水平高于8微克/毫升的患者之间，PMN杀菌能力存在显著差异。当茶碱水平高于8微克/毫升时，患者和对照人群的PMN杀菌能力均降低。此外，接受茶碱治疗的患者的PMN杀菌能力出现了短暂但显著的与药物无关的降低。
