Wieland H, Meissner-Heins H, Heins C, Seidel D
Klin Wochenschr. 1982 Apr 1;60(7):343-8. doi: 10.1007/BF01721624.
The aim of this study was to investigate whether quantification of Lipoprotein X (LP-X) through its cholesterol moiety is advantageous in the differential diagnosis of obstructive jaundice. In the case of mechanic cholestasis, LP-X cholesterol never exceeds 22% of the total serum cholesterol. Lipoprotein-X cholesterol exceeded 70 mg/dl in the plasma of 85% of all cases of acute hepatitis. The combination of lipoprotein with the activities of alkaline phosphatase and GPT allows the recognition of almost 80% of cases acute hepatitis and thereby excludes all other causes of obstructive jaundice. In addition, 84% of all patients investigated can be correctly classified using a combination of LP-X with classical parameters for cholestasis. The concentration of LP-X cholesterol alone apparently is as powerful as the usually used clinical chemical parameters. A combination of lipoprotein and the classical parameters allows a better differentiation of cholestatic liver disease with regard to the underlying cause as it is possible with each group of parameters alone.
本研究的目的是探讨通过脂蛋白X（LP-X）的胆固醇部分进行定量分析，在梗阻性黄疸的鉴别诊断中是否具有优势。在机械性胆汁淤积的情况下，LP-X胆固醇含量从不超过血清总胆固醇的22%。在85%的急性肝炎病例血浆中，脂蛋白-X胆固醇超过70mg/dl。脂蛋白与碱性磷酸酶和谷丙转氨酶活性相结合，几乎能识别80%的急性肝炎病例，从而排除梗阻性黄疸的所有其他病因。此外，使用LP-X与胆汁淤积的经典参数相结合，可对84%的受调查患者进行正确分类。仅LP-X胆固醇的浓度显然与通常使用的临床化学参数一样有效。脂蛋白与经典参数相结合，能更好地区分胆汁淤积性肝病的潜在病因，这是单独使用每组参数所无法做到的。
