Labaille T, Samii K, Mann C, Noviant Y
Nouv Presse Med. 1982 Apr 10;11(17):1309-11.
In 20 elderly patients who underwent cholecystectomy post-operative analgesia was obtained with morphine given either subcutaneously (n = 10) or epidurally (n = 10). Both groups were comparable as to age and pre-operative respiratory function values. On the first post-operative day, vital capacity, forced expiratory volume in one second and and paO2 were significantly higher in the epidural morphine group (respectively 70 +/- 6 p. cent and 68 +/- 6 p. cent of pre-operative values, and 74 +/- 3 mmHg) (mean +/- s.e.m.) than in the subcutaneous morphine group, where the corresponding figures were 52 +/- 4 p. cent, 48 +/- 5 p. cent and 63 +/- 2 mmHg respectively. PaCO2 was unchanged in both groups. These data indicate that epidural morphine analgesia to some extent reduces the post-operative respiratory dysfunction observed after abdominal surgery.
20例接受胆囊切除术的老年患者术后分别采用皮下注射吗啡（n = 10）或硬膜外注射吗啡（n = 10）进行镇痛。两组患者在年龄和术前呼吸功能值方面具有可比性。术后第一天，硬膜外吗啡组的肺活量、一秒用力呼气量和动脉血氧分压显著高于皮下吗啡组（分别为术前值的70±6%和68±6%，以及74±3 mmHg）（均值±标准误），皮下吗啡组的相应数值分别为52±4%、48±5%和63±2 mmHg。两组患者的动脉血二氧化碳分压均无变化。这些数据表明，硬膜外吗啡镇痛在一定程度上可减轻腹部手术后出现的术后呼吸功能障碍。
