Pradalier A, Dry J, Willer J C, Boureau F
Pathol Biol (Paris). 1980 Sep;28(7):462-4.
Using electrophysiological methods for studying pain in human, the authors have studied comparatively the sensation of pain and the threshold of a nociceptive flexion reflex of the lower limb, both elicited by electrical stimulation of sural nerve in 20 obese women (weight greater than or equal to 30 p. 100 of ideal weight) and 14 normal weighing women as controls. In obeses, the threshold of the nociceptive flexion reflex is very significantly lower (5,4 +/- 2 mA in obesity, 9,7 +/- 1,6 mA in controls p < 0,0001). The authors suggests an hypothesis of insufficiency of endogenous opiate releasing in human obesity.
作者采用电生理方法研究人类疼痛，比较了20名肥胖女性（体重≥理想体重的30%）和14名正常体重女性作为对照，通过电刺激腓肠神经引发的下肢疼痛感觉和伤害性屈曲反射阈值。在肥胖者中，伤害性屈曲反射阈值显著更低（肥胖者为5.4±2毫安，对照组为9.7±1.6毫安，p<0.0001）。作者提出了人类肥胖中内源性阿片释放不足的假说。
