• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于一般约束条件的核酸序列比较分析。

Comparative analysis of nucleic acid sequences by their general constraints.

作者信息

Lipman D J, Maizel J

出版信息

Nucleic Acids Res. 1982 Apr 24;10(8):2723-39. doi: 10.1093/nar/10.8.2723.

DOI:10.1093/nar/10.8.2723
PMID:7079183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC320646/
Abstract

We describe two measures of a nucleic acid sequence, derived from Information Theory, which characterize the constraints toward nonuniform base composition, and the constraints on the ordering of the bases. These two measures distinguish extra-chromosomal coding sequences from all other coding sequences examined. The two measures separate eukaryotic coding sequences into two groups: those with introns and those without introns. We have also found a relationship between the general constraints of a subsequence and its degree of conservation in related genes.

摘要

我们描述了两种源自信息论的核酸序列度量方法，它们分别表征了对非均匀碱基组成的限制以及对碱基排序的限制。这两种度量方法可将染色体外编码序列与所研究的所有其他编码序列区分开来。这两种度量方法还将真核生物编码序列分为两组：有内含子的和没有内含子的。我们还发现了子序列的一般限制与其在相关基因中的保守程度之间的关系。

相似文献

1
Comparative analysis of nucleic acid sequences by their general constraints.基于一般约束条件的核酸序列比较分析。
Nucleic Acids Res. 1982 Apr 24;10(8):2723-39. doi: 10.1093/nar/10.8.2723.
2
A prevalent persistent global nonrandomness that distinguishes coding and non-coding eucaryotic nuclear DNA sequences.一种普遍存在的持续性全球非随机性，它区分了编码和非编码真核细胞核DNA序列。
J Mol Evol. 1983;19(2):122-33. doi: 10.1007/BF02300750.
3
Classifying nucleic acid sub-sequences as introns or exons using genetic programming.使用遗传编程将核酸子序列分类为内含子或外显子。
Proc Int Conf Intell Syst Mol Biol. 1995;3:162-9.
4
Origination of the split structure of spliceosomal genes from random genetic sequences.剪接体基因的分裂结构源于随机遗传序列。
PLoS One. 2008;3(10):e3456. doi: 10.1371/journal.pone.0003456. Epub 2008 Oct 20.
5
Markov chain analysis finds a significant influence of neighboring bases on the occurrence of a base in eucaryotic nuclear DNA sequences both protein-coding and noncoding.马尔可夫链分析发现，在真核细胞核DNA序列（包括蛋白质编码序列和非编码序列）中，相邻碱基对某一碱基出现的概率有显著影响。
J Mol Evol. 1984;21(3):278-88. doi: 10.1007/BF02102360.
6
The codon preference plot: graphic analysis of protein coding sequences and prediction of gene expression.密码子偏好性图：蛋白质编码序列的图形分析及基因表达预测
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):539-49. doi: 10.1093/nar/12.1part2.539.
7
Evolution of base composition in the insulin and insulin-like growth factor genes.胰岛素及胰岛素样生长因子基因中碱基组成的演变
Mol Biol Evol. 1994 Nov;11(6):875-85. doi: 10.1093/oxfordjournals.molbev.a040170.
8
Origin of eukaryotic introns: a hypothesis, based on codon distribution statistics in genes, and its implications.真核生物内含子的起源：基于基因中密码子分布统计的一种假说及其影响。
Proc Natl Acad Sci U S A. 1986 Apr;83(7):2133-7. doi: 10.1073/pnas.83.7.2133.
9
Asynchronous distance between homologous DNA sequences.同源DNA序列之间的异步距离。
Biometrics. 1987 Jun;43(2):261-76.
10
Prediction of function in DNA sequence analysis.DNA序列分析中的功能预测
J Comput Biol. 1995 Spring;2(1):87-115. doi: 10.1089/cmb.1995.2.87.

引用本文的文献

1
Hierarchical analysis of influenza A hemagglutinin gene sequences.甲型流感血凝素基因序列的层次分析
Nucleic Acids Res. 1982 Sep 11;10(17):5375-89. doi: 10.1093/nar/10.17.5375.
2
Signal search analysis: a new method to localize and characterize functionally important DNA sequences.信号搜索分析：一种定位和表征功能重要DNA序列的新方法。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):287-305. doi: 10.1093/nar/12.1part1.287.
3
Nucleotide sequence and transcription analysis of a linear DNA plasmid associated with the killer character of the yeast Kluyveromyces lactis.与乳酸克鲁维酵母杀伤特性相关的线性DNA质粒的核苷酸序列及转录分析
Nucleic Acids Res. 1984 Aug 10;12(15):6011-30. doi: 10.1093/nar/12.15.6011.
4
Strong doublet preferences in nucleotide sequences and DNA geometry.核苷酸序列和DNA几何结构中强烈的双峰偏好。
J Mol Evol. 1984;20(2):111-9. doi: 10.1007/BF02257371.
5
Sequence homologies in the protamine gene family of rainbow trout.虹鳟鱼精蛋白基因家族中的序列同源性。
Nucleic Acids Res. 1983 Jul 25;11(14):4907-22. doi: 10.1093/nar/11.14.4907.
6
A transcriptional barrier to expression of cloned toxin genes of the linear plasmid k1 of Kluyveromyces lactis: evidence that native k1 has novel promoters.乳酸克鲁维酵母线性质粒k1克隆毒素基因表达的转录障碍：天然k1具有新型启动子的证据。
Nucleic Acids Res. 1988 Aug 11;16(15):7333-50. doi: 10.1093/nar/16.15.7333.
7
Nonuniformity of nucleotide substitution rates in molecular evolution: computer simulation and analysis of 5S ribosomal RNA sequences.分子进化中核苷酸替代率的不均匀性：5S核糖体RNA序列的计算机模拟与分析
J Mol Evol. 1987;26(3):226-51. doi: 10.1007/BF02099855.
8
Informational parameters and randomness of mitochondrial DNA.线粒体DNA的信息参数与随机性
J Mol Evol. 1988;27(2):109-13. doi: 10.1007/BF02138369.
9
Codon preference and primary sequence structure in protein-coding regions.蛋白质编码区域的密码子偏好性和一级序列结构
Bull Math Biol. 1989;51(1):95-115. doi: 10.1007/BF02458838.

本文引用的文献

1
DNA sequencing and gene structure.DNA测序与基因结构。
Science. 1981 Dec 18;214(4527):1305-12. doi: 10.1126/science.7313687.
2
Identification of common molecular subsequences.常见分子子序列的鉴定
J Mol Biol. 1981 Mar 25;147(1):195-7. doi: 10.1016/0022-2836(81)90087-5.
3
The structure and evolution of the human beta-globin gene family.人类β-珠蛋白基因家族的结构与进化
Cell. 1980 Oct;21(3):653-68. doi: 10.1016/0092-8674(80)90429-8.
4
Enhanced graphic matrix analysis of nucleic acid and protein sequences.核酸和蛋白质序列的增强图形矩阵分析
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7665-9. doi: 10.1073/pnas.78.12.7665.
5
Base substitutions, length differences and DNA strand asymmetries in the human G gamma and A gamma fetal globin gene region.人类γ珠蛋白胎儿基因区域中的碱基替换、长度差异和DNA链不对称性。
Cell. 1981 Nov;26(3 Pt 1):345-53. doi: 10.1016/0092-8674(81)90203-8.
6
Why genes in pieces?为什么基因是断裂的？
Nature. 1978 Feb 9;271(5645):501. doi: 10.1038/271501a0.