Bucher P, Bryan B
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):287-305. doi: 10.1093/nar/12.1part1.287.
The generation of "signal search data" represents a general method of describing the common properties of a set of DNA sequences presumed to be functionally analogous. Besides the detailed description of this method we present two computer programs which use signal search data as input data: One that processes them to a "constraint profile" and another one which lists over-represented "signals" of potential functional relevance. To illustrate the possibilities of our method we have analysed a set of transcription initiation sites of sea urchin histone genes.
“信号搜索数据”的生成代表了一种描述一组假定具有功能相似性的DNA序列共同特性的通用方法。除了对该方法的详细描述外,我们还展示了两个将信号搜索数据用作输入数据的计算机程序:一个将它们处理成“约束图谱”,另一个列出可能具有功能相关性的过度表达的“信号”。为了说明我们方法的可能性,我们分析了一组海胆组蛋白基因的转录起始位点。