Gupta C, Goldman A
Science. 1982 May 28;216(4549):994-6. doi: 10.1126/science.7079749.
The influence of the H-2 histocompatibility complex on glucocorticoid receptor levels, and the biochemical response of glucocorticoid action measured as the degree of inhibition of prostaglandin production, has been studied in the mouse thymus and lung. The B10A (H-2a) strain of mice has significantly higher glucocorticoid receptor levels and a significantly greater biochemical response to glucocorticoid than the B10 (H-2b) strain, which differs from B10A within the H-2 complex only. Thus, the anti-inflammatory hormone response of glucocorticoids is correlated to hormone receptor level, both of which are influenced by the H-2 locus.
在小鼠胸腺和肺中，研究了H-2组织相容性复合体对糖皮质激素受体水平的影响，以及以前列腺素产生的抑制程度衡量的糖皮质激素作用的生化反应。B10A（H-2a）品系小鼠的糖皮质激素受体水平显著高于B10（H-2b）品系，且对糖皮质激素的生化反应也显著更强，而B10与B10A仅在H-2复合体内存在差异。因此，糖皮质激素的抗炎激素反应与激素受体水平相关，二者均受H-2基因座的影响。
