人类白细胞抗原（HLA）抗原、植物血凝素刺激及皮质类固醇反应。
HLA antigens, phytohemagglutinin stimulation, and corticosteroid response.
作者信息
Erickson R P, Heidel L A, Kapur J J, Karolyi J M, Odenheimer D J, Pairitz G L, Schultz J S, Sing C F
机构信息
Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI 48109-0010, USA.
出版信息
Am J Hum Genet. 1985 Jul;37(4):761-70.
Although it is clear that the major histocompatibility complex is associated with lymphocyte glucocorticoid sensitivity in mice, there has been less evidence for a similar relationship in man. We have typed 158 individuals for: (1) 13 A locus and 16 B locus antigens, (2) degree of stimulation of their purified lymphocytes by phytohemagglutinin A (PHA), and (3) degree of inhibition of the PHA stimulation by prednisolone and prednisolone-21-hemisuccinate. In contrasts of individuals with a particular antigen (homozygous or heterozygous) with all remaining individuals, HLA-B7 was found to be associated with an enhancing effect on the log stimulation by PHA while other antigens of these series did not have significant associations. In similar contrasts, A10 was associated with a decrease in sensitivity to glucocorticoid inhibition of PHA stimulation as measured by the log I50 of the suppression of PHA stimulation. Other antigens of these series were not found to have significant associations with the glucocorticoid sensitivity of lymphocytes in this assay.
虽然很明显主要组织相容性复合体与小鼠淋巴细胞的糖皮质激素敏感性相关，但在人类中，类似关系的证据较少。我们对158名个体进行了如下分型：（1）13种A位点和16种B位点抗原，（2）其纯化淋巴细胞受植物血凝素A（PHA）刺激的程度，以及（3）泼尼松龙和泼尼松龙-21-半琥珀酸对PHA刺激的抑制程度。在具有特定抗原（纯合或杂合）的个体与所有其余个体的对比中，发现HLA - B7与PHA对数刺激的增强作用相关，而该系列的其他抗原无显著关联。在类似的对比中，A10与PHA刺激的糖皮质激素抑制敏感性降低相关，通过PHA刺激抑制的对数I50来衡量。在该检测中，未发现该系列的其他抗原与淋巴细胞的糖皮质激素敏感性有显著关联。
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