人类6号染色体的分子遗传学
The molecular genetics of human chromosome 6.
作者信息
Cunliffe V, Trowsdale J
机构信息
Human Immunogenetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London.
出版信息
J Med Genet. 1987 Nov;24(11):649-58. doi: 10.1136/jmg.24.11.649.
Abstract
Chromosome 6 contains several clinically important markers as well as classical enzyme loci, proto-oncogenes, and a growing number of anonymous DNA restriction fragment length polymorphisms (RFLPs). It is also of unique interest because of the location of the major histocompatibility complex (MHC) on the short arm, at 6p21.3. The MHC is one of the most detailed areas of the human genetic map to date and many important diseases, some of a suspected autoimmune aetiology, are associated with it.
摘要
6号染色体包含几个临床上重要的标记以及经典的酶基因座、原癌基因，还有越来越多的匿名DNA限制性片段长度多态性（RFLP）。它也因其独特性而备受关注，因为主要组织相容性复合体（MHC）位于短臂6p21.3处。MHC是迄今为止人类遗传图谱中最详细的区域之一，许多重要疾病，其中一些怀疑是自身免疫病因，都与之相关。
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