Konstantinidis A, Smulow J B, Sonnenschein C
Science. 1982 Jun 11;216(4551):1235-7. doi: 10.1126/science.7079755.
Tumors in the soft tissues of the oral cavity of rats developed at predetermined sites as a result of a combination of an intraperitoneal injection of a direct-acting carcinogen. N-nitro-N-methylurea, and a continuous irritation of the buccal mucosa by a stainless steel wire. The incidence of histologically malignant tumors was significantly higher in the irritated area than in any other area of the body. These results constitute evidence for a carcinogenic mechanism whereby the cells that develop into tumors may require the promotional effect of a nonspecific, nonmutagenic stimulus.
