使用ε-氨基己酸、卡那霉素和利血平对脑动脉瘤破裂患者进行药物治疗。

Medical management of patients following a ruptured cerebral aneurysm, with epsilon-aminocaproic acid, kanamycin, and reserpine.

作者信息

Knuckey N W, Stokes B A

出版信息

Surg Neurol. 1982 Mar;17(3):181-5. doi: 10.1016/0090-3019(82)90271-3.

Abstract

Patients suffering from a subarachnoid hemorrhage who were admitted to the Neurosurgical Unit of the Royal Perth Hospital during the period 1971 to 1979 were assessed with regard to the effectiveness of preoperative treatment with epsilon-aminocaproic acid, kanamycin, and reserpine. Forty-two patients who were treated with epsilon-aminocaproic acid had a rebleed rate of 2.3% compared to 1 9.7% rebleed rate in appropriately selected controls. Patients treated with kanamycin and reserpine had a preoperative cerebral vasospasm rate of 32% compared to a 26% rate in controls; however, kanamycin and reserpine were found useful for decreasing the postoperative complications of cerebral vasospasm.

摘要

1971年至1979年期间入住皇家珀斯医院神经外科的蛛网膜下腔出血患者，接受了关于术前使用ε-氨基己酸、卡那霉素和利血平治疗效果的评估。接受ε-氨基己酸治疗的42例患者再出血率为2.3%，而在适当选择的对照组中再出血率为19.7%。接受卡那霉素和利血平治疗的患者术前脑血管痉挛发生率为32%，而对照组为26%；然而，发现卡那霉素和利血平有助于降低术后脑血管痉挛的并发症。