颅内动脉瘤破裂所致蛛网膜下腔出血术前管理中的抗纤维蛋白溶解治疗
Anti-fibrinolytic treatment in the pre-operative management of subarachnoid haemorrhage caused by ruptured intracranial aneurysm.
作者信息
Ameen A A, Illingworth R
出版信息
J Neurol Neurosurg Psychiatry. 1981 Mar;44(3):220-6. doi: 10.1136/jnnp.44.3.220.
Abstract
One hundred consecutive patients treated with epsilon aminocaproic acid 24 grams daily prior to surgery for ruptured intracranial aneurysms have been compared with the previous 100 patients managed similarly but without anti-fibrinolytic drugs. No other alterations in management were made and the two series are closely comparable in all other respects. Fewer episodes of recurrent haemorrhage and deaths from this cause occurred in the treated patients, but more cases of cerebral ischaemia occurred. Neither difference is statistically significant and overall more deaths occurred in the patients treated with antifibrinolytic drugs. The value of this method of treatment in the management of aneurysmal subarachnoid haemorrhage is questioned.
摘要
100例颅内动脉瘤破裂患者在手术前每天接受24克ε-氨基己酸治疗，将其与之前100例接受类似治疗但未使用抗纤维蛋白溶解药物的患者进行了比较。治疗管理上未作其他改变，两组在所有其他方面具有高度可比性。接受治疗的患者复发性出血事件及由此导致的死亡较少，但脑缺血病例较多。这两个差异均无统计学意义，总体上接受抗纤维蛋白溶解药物治疗的患者死亡更多。这种治疗方法在动脉瘤性蛛网膜下腔出血管理中的价值受到质疑。
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本文引用的文献
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Hypothermia, and interruption of carotid, or carotid and vertebral circulation, in the surgical management of intracranial aneurysms.低温以及在颅内动脉瘤手术治疗中阻断颈动脉或颈动脉与椎动脉循环。
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Report on the cooperative study of intracranial aneurysms and subarachnoid hemorrhage. Section VII. I. Evaluation of the conservative management of ruptured intracranial aneurysms.颅内动脉瘤与蛛网膜下腔出血合作研究报告。第七部分。一、破裂颅内动脉瘤保守治疗的评估。
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