头孢孟多在婴幼儿及儿童中的药代动力学
Pharmacokinetics of cefamandole in infants and children.
作者信息
Walker S H, Gahol V P
出版信息
Antimicrob Agents Chemother. 1978 Sep;14(3):315-7. doi: 10.1128/AAC.14.3.315.
Abstract
In infants less than 3 months of age, the serum concentration of cefamandole during therapy was higher and more prolonged than that in children older than 1 year. A dosage of 37 mg/kg administered intravenously at 6-h intervals provided a serum concentration in excess of the minimum inhibitory concentrations of common bacterial pathogens for 4 h, and in young infants for 5 h, after dosing.
摘要
在3个月龄以下的婴儿中，治疗期间头孢孟多的血清浓度高于1岁以上儿童，且持续时间更长。以37mg/kg的剂量每6小时静脉给药一次，给药后血清浓度超过常见细菌病原体最低抑菌浓度的时间在儿童中为4小时，在幼儿中为5小时。
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