头孢孟多：体外及临床药代动力学
Cefamandole: in vitro and clinical pharmacokinetics.
作者信息
Griffith R S, Black H R, Brier G L, Wolny J D
出版信息
Antimicrob Agents Chemother. 1976 Nov;10(5):814-23. doi: 10.1128/AAC.10.5.814.
Abstract
Cefamandole has a broader spectrum and greater potency than the other cephalosporins. It includes Haemophilus influenzae, most strains of Enterobacter, and many strains of indole-positive Proteus and Bacteroides, with a lower minimal inhibitory concentration for Escherichia coli, Klebsiella, etc. Concentrations of drug in the serum after the parenteral injection of cefamandole exceed manyfold the minimal inhibitory concentrations of over 82% of the bacteria studied. Approximately 65 to 85% is excreted in a biologically active form in the urine. This antibiotic offers advantages of antibacterial effectiveness and at the same time retains the safety of penicillin G and cephalothin in animals.
摘要
头孢孟多的抗菌谱比其他头孢菌素更广，抗菌活性更强。它包括流感嗜血杆菌、大多数肠杆菌菌株、许多吲哚阳性变形杆菌和拟杆菌菌株，对大肠杆菌、克雷伯菌等的最低抑菌浓度较低。静脉注射头孢孟多后血清中的药物浓度超过所研究的82%以上细菌的最低抑菌浓度许多倍。约65%至85%以生物活性形式经尿液排泄。这种抗生素具有抗菌效果好的优点，同时在动物身上保持了青霉素G和头孢噻吩的安全性。
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Cefamandole: in vitro and clinical pharmacokinetics.头孢孟多：体外及临床药代动力学
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本文引用的文献
1
Susceptibility of clinical isolates of bacteria to cefoxitin and cephalothin.临床分离细菌对头孢西丁和头孢噻吩的敏感性。
Antimicrob Agents Chemother. 1974 Sep;6(3):320-3. doi: 10.1128/AAC.6.3.320.
2
Cefamandole, a cephalosporin antibiotic with an unusually wide spectrum of activity.头孢孟多，一种具有异常广泛活性谱的头孢菌素抗生素。
Antimicrob Agents Chemother. 1974 Aug;6(2):177-82. doi: 10.1128/AAC.6.2.177.
3
The cephalosporins. Microbiological, chemical, and pharmacological properties and use in chemotherapy of infection.头孢菌素。微生物学、化学及药理学特性以及在感染化疗中的应用。
Ann Intern Med. 1970 May;72(5):729-39. doi: 10.7326/0003-4819-72-5-729.
4
Activity of five aminoglycoside antibiotics in vitro against gram-negative bacilli and Staphylococcus aureus.五种氨基糖苷类抗生素对革兰氏阴性杆菌和金黄色葡萄球菌的体外活性。
Antimicrob Agents Chemother. 1973 Dec;4(6):617-25. doi: 10.1128/AAC.4.6.617.
5
Antibacterial activity of cefamandole, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cephalexin.新型头孢菌素抗生素头孢孟多与头孢噻啶、头孢噻吩和头孢氨苄的抗菌活性比较。
Antimicrob Agents Chemother. 1973 Jun;3(6):657-61. doi: 10.1128/AAC.3.6.657.
6
Pharmacokinetics of cefazolin compared with four other cephalosporins.头孢唑林与其他四种头孢菌素的药代动力学比较。
J Infect Dis. 1973 Oct;128:Suppl:S341-6. doi: 10.1093/infdis/128.supplement_2.s341.
7
The in vitro spectrum of the cephalosporins.头孢菌素的体外抗菌谱。
Mayo Clin Proc. 1976 Apr;51(4):237-50.
8
Effect of inoculum and of beta-lactamase on the anti-staphylococcal activity of thirteen penicillins and cephalosporins.接种量及β-内酰胺酶对13种青霉素和头孢菌素抗葡萄球菌活性的影响。
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9
Activity of cefamandole and other cephalosporins against aerobic and anaerobic bacteria.头孢孟多及其他头孢菌素对需氧菌和厌氧菌的活性。
Antimicrob Agents Chemother. 1976 May;9(5):852-5. doi: 10.1128/AAC.9.5.852.
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