Kaneshige H, Endoh M, Tomino Y, Nomoto Y, Sakai H, Arimori S
Tokai J Exp Clin Med. 1982 Jan;7(1):77-80.
Phagocytosis and intracellular killing of Staphylococcus aureus by granulocytes were examined in diabetic patients. There was no significant difference in the phagocytic activity of granulocytes between control and diabetic-subjects. However, intracellular killing by granulocytes was significantly reduced in insulin-treated diabetic patients compared with control subjects. No significant difference was observed between controls and diet-treated diabetic patients. It is suggested that decreased activity of intracellular killing of bacteria in granulocytes is one of the mechanisms of increased susceptibility to infection in patients with advanced stages of diabetes mellitus.
对糖尿病患者中粒细胞对金黄色葡萄球菌的吞噬作用和细胞内杀伤作用进行了检测。对照组和糖尿病患者的粒细胞吞噬活性没有显著差异。然而，与对照组相比，胰岛素治疗的糖尿病患者中粒细胞的细胞内杀伤作用显著降低。在对照组和饮食治疗的糖尿病患者之间未观察到显著差异。提示粒细胞内细菌杀伤活性降低是晚期糖尿病患者易感染的机制之一。
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