低氧血症对动物氨基糖苷类药物血清药代动力学的影响。
Effects of hypoxemia upon aminoglycoside serum pharmacokinetics in animals.
作者信息
Mirhij N J, Roberts R J, Myers M G
出版信息
Antimicrob Agents Chemother. 1978 Sep;14(3):344-7. doi: 10.1128/AAC.14.3.344.
Abstract
Hypoxemia causes significant alterations in aminoglycoside serum pharmacokinetics in adult rats and newborn rabbits. The aminoglycoside serum clearances were diminished in hypoxemic animals. Comparisons of intravenous and intramuscular administration imply a delay in uptake of drug from intramuscular injection sites under hypoxemic conditions.
摘要
低氧血症会导致成年大鼠和新生兔体内氨基糖苷类药物的血清药代动力学发生显著改变。低氧血症动物的氨基糖苷类药物血清清除率降低。静脉注射和肌肉注射的比较表明，在低氧血症条件下，肌肉注射部位药物的吸收会延迟。
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2
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3
Effects of low oxygen and of carbon monoxide on the renal circulation in unanesthetized rabbits.低氧和一氧化碳对未麻醉家兔肾循环的影响。
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4
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5
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6
7
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