胎龄、出生体重和低氧血症对婴儿血清中阿米卡星药代动力学的影响。
Effects of gestational age, birth weight, and hypoxemia on pharmacokinetics of amikacin in serum of infants.
作者信息
Myers M G, Roberts R J, Mirhij N J
出版信息
Antimicrob Agents Chemother. 1977 Jun;11(6):1027-32. doi: 10.1128/AAC.11.6.1027.
Abstract
The serum pharmacokinetics of amikacin were studied in 36 infants treated for suspected bacterial infection. A prolonged serum half-life was associated with the related variables of birth at an early gestational age, low birth weight, and hypoxemia. A postnatal age effect was not apparent when hypoxemic infants were excluded.
摘要
对36例疑似细菌感染的婴儿进行了阿米卡星的血清药代动力学研究。血清半衰期延长与孕早期出生、低出生体重和低氧血症等相关变量有关。排除低氧血症婴儿后，出生后年龄效应不明显。
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