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1
Effects of gestational age, birth weight, and hypoxemia on pharmacokinetics of amikacin in serum of infants.胎龄、出生体重和低氧血症对婴儿血清中阿米卡星药代动力学的影响。
Antimicrob Agents Chemother. 1977 Jun;11(6):1027-32. doi: 10.1128/AAC.11.6.1027.
2
Effects of hypoxemia upon aminoglycoside serum pharmacokinetics in animals.低氧血症对动物氨基糖苷类药物血清药代动力学的影响。
Antimicrob Agents Chemother. 1978 Sep;14(3):344-7. doi: 10.1128/AAC.14.3.344.
3
Amikacin dosage in the preterm newborn.
J Antimicrob Chemother. 1979 Sep;5(5):527-30. doi: 10.1093/jac/5.5.527.
4
The effect of chronologic age on the serum concentrations of amikacin in sick term and premature infants.实足年龄对患病足月儿和早产儿血清阿米卡星浓度的影响。
J Pediatr. 1981 Apr;98(4):636-40. doi: 10.1016/s0022-3476(81)80783-4.
5
Kinetics and dose calculations of amikacin in the newborn.新生儿中阿米卡星的动力学及剂量计算
Clin Pharmacol Ther. 1976 Jul;20(1):59-66. doi: 10.1002/cpt197620159.
6
Amikacin in newborn infants: comparative pharmacology with kanamycin and clinical efficacy in 45 neonates with bacterial diseases.新生儿使用阿米卡星：与卡那霉素的比较药理学及对45例患细菌性疾病新生儿的临床疗效
Antimicrob Agents Chemother. 1976 Aug;10(2):205-10. doi: 10.1128/AAC.10.2.205.
7
Monitoring of amikacin in the neonate.新生儿中阿米卡星的监测。
Ther Drug Monit. 1983 Jun;5(2):179-83. doi: 10.1097/00007691-198306000-00005.
8
[A pharmacokinetic basis for schedules for administering amikacin to newborn infants].
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9
Evaluation of amikacin dosage regimes in the low and very low birthweight newborn.低出生体重和极低出生体重新生儿阿米卡星给药方案的评估
Infection. 1980;8 Suppl 3:S 239-42. doi: 10.1007/BF01639588.
10
Plasma nonesterified fatty acid and blood glucose levels in healthy and hypoxemic newborn infants.
J Pediatr. 1974 Apr;84(4):578-84. doi: 10.1016/s0022-3476(74)80685-2.

引用本文的文献

1
Evaluation of amikacin dosage regimes in the low and very low birthweight newborn.低出生体重和极低出生体重新生儿阿米卡星给药方案的评估
Infection. 1980;8 Suppl 3:S 239-42. doi: 10.1007/BF01639588.
2
Modification in the pharmacokinetics of amikacin during development.阿米卡星在研发过程中的药代动力学变化。
Eur J Clin Pharmacol. 1982;23(2):155-60. doi: 10.1007/BF00545971.
3
Incidence of potentially toxic concentrations of gentamicin in the neonate.新生儿中庆大霉素潜在毒性浓度的发生率。
Arch Dis Child. 1983 Nov;58(11):897-900. doi: 10.1136/adc.58.11.897.
4
Serum level monitoring of antibacterial drugs. A review.抗菌药物的血清水平监测。综述。
Clin Pharmacokinet. 1984 Nov-Dec;9(6):475-92. doi: 10.2165/00003088-198409060-00001.
5
Pharmacokinetics and bacteriological efficacy of mezlocillin in experimental Escherichia coli and Listeria monocytogenes meningitis.美洛西林在实验性大肠杆菌和单核细胞增生李斯特菌脑膜炎中的药代动力学及细菌学疗效
Antimicrob Agents Chemother. 1984 Apr;25(4):427-32. doi: 10.1128/AAC.25.4.427.
6
Anticonvulsants in the newborn period.新生儿期的抗惊厥药。
Indian J Pediatr. 1985 Sep-Oct;52(418):513-26. doi: 10.1007/BF02751028.
7
Effect of pentobarbital anesthesia on amikacin concentrations in plasma and perilymph and evaluation of multiple sampling in perilymph of guinea pigs.戊巴比妥麻醉对豚鼠血浆和外淋巴中阿米卡星浓度的影响及外淋巴多次采样的评估
Antimicrob Agents Chemother. 1985 May;27(5):720-3. doi: 10.1128/AAC.27.5.720.
8
Antibiotic disposition in experimental pneumonic pasteurellosis: gentamicin and tylosin.实验性肺炎巴氏杆菌病中抗生素的处置：庆大霉素和泰乐菌素
Can J Vet Res. 1986 Apr;50(2):193-9.
9
The effect of respiratory disorders on clinical pharmacokinetic variables.呼吸系统疾病对临床药代动力学变量的影响。
Clin Pharmacokinet. 1990 Dec;19(6):462-90. doi: 10.2165/00003088-199019060-00004.
10
Effects of hypoxemia upon aminoglycoside serum pharmacokinetics in animals.低氧血症对动物氨基糖苷类药物血清药代动力学的影响。
Antimicrob Agents Chemother. 1978 Sep;14(3):344-7. doi: 10.1128/AAC.14.3.344.

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RENAL HEMODYNAMICS.肾血流动力学
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Effects of low oxygen and of carbon monoxide on the renal circulation in unanesthetized rabbits.低氧和一氧化碳对未麻醉家兔肾循环的影响。
Circ Res. 1963 Apr;12:361-74. doi: 10.1161/01.res.12.4.361.
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Clinical assessment of gestational age in the newborn infant.新生儿胎龄的临床评估。
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Pharmacology of gentamicin in man.庆大霉素在人体中的药理学。
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Control of renal circulation in the fetus.
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The evolution and spread of gentamicin-resistant Pseudomonads.庆大霉素耐药假单胞菌的进化与传播
J Trauma. 1971 Jul;11(7):586-9. doi: 10.1097/00005373-197107000-00009.
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Gentamicin in the neonatal period.新生儿期的庆大霉素。
Am J Dis Child. 1970 Dec;120(6):524-33. doi: 10.1001/archpedi.1970.02100110072007.
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Gentamicin.庆大霉素
Med Clin North Am. 1970 Sep;54(5):1305-15.
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Activity of five aminoglycoside antibiotics in vitro against gram-negative bacilli and Staphylococcus aureus.五种氨基糖苷类抗生素对革兰氏阴性杆菌和金黄色葡萄球菌的体外活性。
Antimicrob Agents Chemother. 1973 Dec;4(6):617-25. doi: 10.1128/AAC.4.6.617.
10
Enzymatic acetylation as a means of determining serum aminoglycoside concentrations.酶促乙酰化法作为测定血清氨基糖苷类药物浓度的一种手段。
Antimicrob Agents Chemother. 1973 Oct;4(4):497-9. doi: 10.1128/AAC.4.4.497.

胎龄、出生体重和低氧血症对婴儿血清中阿米卡星药代动力学的影响。

Effects of gestational age, birth weight, and hypoxemia on pharmacokinetics of amikacin in serum of infants.

作者信息

Myers M G, Roberts R J, Mirhij N J

出版信息

Antimicrob Agents Chemother. 1977 Jun;11(6):1027-32. doi: 10.1128/AAC.11.6.1027.

DOI:10.1128/AAC.11.6.1027
PMID:879747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352123/
Abstract

The serum pharmacokinetics of amikacin were studied in 36 infants treated for suspected bacterial infection. A prolonged serum half-life was associated with the related variables of birth at an early gestational age, low birth weight, and hypoxemia. A postnatal age effect was not apparent when hypoxemic infants were excluded.

摘要

对36例疑似细菌感染的婴儿进行了阿米卡星的血清药代动力学研究。血清半衰期延长与孕早期出生、低出生体重和低氧血症等相关变量有关。排除低氧血症婴儿后，出生后年龄效应不明显。