两性霉素B和5-氟胞嘧啶：对淋巴细胞功能的体外作用
Amphotericin B and 5-fluorocytosine: in vitro effects on lymphocyte function.
作者信息
Roselle G A, Kauffman C A
出版信息
Antimicrob Agents Chemother. 1978 Sep;14(3):398-402. doi: 10.1128/AAC.14.3.398.
The effects of amphotericin B, 5-fluorocytosine, and the combination of both drugs on lymphocyte function in vitro were investigated. Amphotericin B, alone or in combination with 5-fluorocytosine, significantly suppressed both spontaneous lymphocyte transformation and the response of lymphocytes to stimulation with streptokinase-streptodornase. 5-Fluorocytosine had no effect on spontaneous or antigen-induced transformation. Lymphocyte responses to the mitogens phytohemagglutinin and concanavalin A were not changed by exposure to amphotericin B, 5-fluorocytosine, or the combination of both drugs. T-lymphocyte receptors for sheep erythrocytes and B-lymphocyte surface immunoglobulin and receptors for complement were not changed by treatment with amphotericin B or 5-fluorocytosine.
研究了两性霉素B、5-氟胞嘧啶以及这两种药物联合使用对体外淋巴细胞功能的影响。两性霉素B单独使用或与5-氟胞嘧啶联合使用时，均能显著抑制淋巴细胞的自发转化以及淋巴细胞对链激酶-链道酶刺激的反应。5-氟胞嘧啶对自发或抗原诱导的转化均无影响。暴露于两性霉素B、5-氟胞嘧啶或两种药物联合使用时，淋巴细胞对植物血凝素和刀豆球蛋白A这两种促有丝分裂原的反应未发生改变。用两性霉素B或5-氟胞嘧啶处理后，绵羊红细胞的T淋巴细胞受体、B淋巴细胞表面免疫球蛋白以及补体受体均未发生改变。
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