Roselle G A, Kauffman C A
Clin Exp Immunol. 1980 Apr;40(1):186-92.
Although single-dose amphotericin B therapy appears to be immunostimulatory in mice, no data are available regarding the effects of chronic anti-fungal drug therapy on the immune system. We studied the effects on the guinea-pig cellular immune system of 4 weeks of treatment with amphotericin B, 5-fluorocytosine, or the combination of both drugs. The in vitro lymphocyte response to phytohaemagglutinin and the specific antigen, picryl human serum albumin (picHSA), were not affected by anti-fungal drug treatment. At 1.5 weeks of therapy with amphotericin B, skin test reactivity to picHSA was significantly reduced but returned toward normal by the end of 3.5 weeks of drug therapy. Macrophage migration inhibitory factor production by guinea-pig peripheral blood lymphocytes was significantly reduced after 4 weeks of amphotericin B therapy. No immunostimulatory properties could be ascribed to amphotericin B. 5-fluorocytosine had no effect on cellular immunity.
虽然单剂量两性霉素B疗法在小鼠中似乎具有免疫刺激作用，但尚无关于慢性抗真菌药物疗法对免疫系统影响的数据。我们研究了两性霉素B、5-氟胞嘧啶或两种药物联合使用4周对豚鼠细胞免疫系统的影响。抗真菌药物治疗未影响体外淋巴细胞对植物血凝素和特异性抗原苦味酰人血清白蛋白（picHSA）的反应。在两性霉素B治疗1.5周时，对picHSA的皮肤试验反应性显著降低，但在药物治疗3.5周结束时恢复正常。两性霉素B治疗4周后，豚鼠外周血淋巴细胞产生的巨噬细胞移动抑制因子显著减少。两性霉素B未表现出免疫刺激特性。5-氟胞嘧啶对细胞免疫没有影响。
