Klimov A N, Petrova-Maslakova L G, Mamontova I F, Parfenova N S, Kovaleva I G
Vopr Med Khim. 1982 Mar-Apr;28(2):122-5.
A ratio of cholesterol esters to free cholesterol was decreased in the total fraction of high density lipoproteins (LPHD) after incubation of the fraction with human aorta intima impaired by atherosclerosis. The same alterations occurred in the reaction of aorta intima with the fraction LPHD3. During incubation of the intima with LPHD2 less distinct decrease was observed in the ratio of cholesterol esters to free cholesterol. The decrease in the ratio of cholesterol fractions, found both in total LPHD and LPHD3, was caused by transfer of free cholesterol from intima cells to LPHD. Thus, LPHD (namely LPHD3 fraction) were able to accept free cholesterol from aorta intima cells; this mechanism is apparently responsible for protective effect of LPHD in atherogenesis.
高密度脂蛋白（LPHD）总组分与人主动脉内膜经动脉粥样硬化损伤后的部分共同孵育后，胆固醇酯与游离胆固醇的比例降低。主动脉内膜与LPHD3组分的反应中也出现了同样的变化。在内膜与LPHD2孵育过程中，胆固醇酯与游离胆固醇的比例降低不太明显。在总LPHD和LPHD3中发现的胆固醇组分比例降低是由于游离胆固醇从内膜细胞转移到LPHD所致。因此，LPHD（即LPHD3组分）能够从主动脉内膜细胞接受游离胆固醇；这种机制显然是LPHD在动脉粥样硬化发生过程中起保护作用的原因。
