[Effect of typhoid endotoxin and its lipid component on the lipid concentration of myocardial tissue of mice].

Content of triacylglycerides and cholesterol esters was rapidly and distinctly increased while di- and monoacylglycerides appeared in heart muscle after intraperitoneal administration of hyphoid endotoxin into mice. Concentration of free fatty acids exceeded 3-fold the initial level within a day. At the same time, content of free cholesterol was also increased. Lipid fractions (lipids A and B) isolated from the lipopolysaccharides altered distinctly the lipid composition in mice myocardium. An increase in acylglycerol content was noted though it was less distinct as compared with the lipopolysaccharide effect. Lipid A and especially lipid B decreased the content of free fatty acids and of free cholesterol in myocardial tissue. Content of total phospholipids was unaltered in heart muscle after the lipopolysaccharide administration but these lipid fractions increased distinctly their content.