Muzhichenko A V, Khardina G A
Vopr Med Khim. 1979 Jul-Aug;25(4):398-402.
Content of phospholipid fractions was altered in mice liver tissue after intraperitoneal administration of typhoid lipopolysaccharide and of lipid A, isolated from the lipopolysaccharide. The intoxication was accompanied by an increase in content of choline-containing phospholipids within 6 and 24 hrs as well as by an alteration in the ratio of the fractions. Effect of lipid A on the tissue phospholipid spectra resembled the effect of the lipopolysaccharide, but was less prolonged. The lipopolysaccharide and lipid A altered the stability of phosphatidyl choline and cardiolipin bonds with the components of liver cells.
在腹腔注射伤寒脂多糖以及从脂多糖中分离出的脂质A后，小鼠肝脏组织中磷脂组分的含量发生了改变。中毒伴随着含胆碱磷脂含量在6小时和24小时内增加，以及各组分比例的改变。脂质A对组织磷脂谱的影响类似于脂多糖的影响，但持续时间较短。脂多糖和脂质A改变了磷脂酰胆碱和心磷脂与肝细胞成分结合的稳定性。
