Vishniakova L A, Vasil'eva M G
Zh Mikrobiol Epidemiol Immunobiol. 1982 Jan(1):40-3.
The virulence of 139 Str. pneumoniae strains was studied. The cultures differing in virulence were found to have the same specific prominence. In most serotypes the LD50 for mice was within greater than 3-5 lg/ml and greater than or equal to 6 lg/ml. Highly virulent cultures comprised a comparatively small number of serotypes. More than half of pneumococcal strains isolated in acute pneumonia possessed the moderate level of pathogenicity for white mice. During the acute phase of inflammatory pulmonary diseases Str. pneumoniae strains with high and moderate virulence prevailed, and at the period of clinical remission those with low virulence.
对139株肺炎链球菌菌株的毒力进行了研究。发现毒力不同的培养物具有相同的特异性特征。在大多数血清型中，小鼠的半数致死剂量（LD50）大于3至5 lg/ml且大于或等于6 lg/ml。高毒力培养物包含相对较少的血清型。在急性肺炎中分离出的肺炎球菌菌株中，超过一半对白鼠具有中等致病水平。在炎症性肺部疾病的急性期，高毒力和中等毒力的肺炎链球菌菌株占优势，而在临床缓解期则是低毒力菌株占优势。
